I have been on methadone for the last 5 years (was at 70mg for the first 4 years and have titrated within the last year down to 50mg). I used to take oxycodone (at high doses but only one daily), and, tbh, I wish o had considered this treatment before being put on a long-acting opioid which now fills my receptors more or less all the time. It is widely acknowledged that Methadone is the most difficult opioid to come off of because of the length of time it takes for the body to adjust and return to pre-defendant states. So i have my doubts about the efficacy of such a short term treatment for such a high receptor-affinity long acting opioid, and I wish to know if this protocol has seen any success (and to what extent) in treating methadone dependance. To be clear, I have not had any active psychological addiction to opioids for many years, but given a rare genetic mutation (compound heterozygous MTHFR), my brain has trouble producing the regular amount of endorphins on its own, and therefore I am extra sensitive to withdrawal. From my POV, it seem like the most effective chance of success for treating this dependency and removing this receptor affinity would be to first switch me back to using a short acting opioid prior to attempting cessation or rapid titration. However, with the opioid epidemic putting increasing pressure on physicians to cover their careers first before always doing what is best for patient care, it seems and uphill battle at best finding an MD who would be willing to oversee and prescribe this transition. 

I look forward to consulting with someone from your clinic to learn more about the realistic potential of what part ANR might play on my effort to free myself from opioid dependable altogether. 

Thank you for your time.

Best regards,

Willow Whitcomb