I'm inquiring on behalf of my brother who was investigating rapid-detox options and asked for my help as a medical professional. I have several questions:
1. I see that there have been studies done on rapid-detox but I cannot locate any on the ANR protocol. Can you point me in the direction of any peer-reviewed studies please?
2. It seems to me (not knowing much about this process) that the first stage of ANR treatment is similar to rapid-detox protocols, using an opioid antagonist and sedation. The latter part (which seems to make ANR unique) focused on re-establishing healthy endorphins is not well-clarified from what I have come across. Can you explain how this process works? What drugs are involved? Please demystify this for me. 
3.  What are the costs associated with this treatment? My brother spent a number of years heavily addicted to oxycotin and was even injecting it (as well as other drugs). He was sober for 3 years without even methadone. Now he is on the highest legal dose of methadone and perhaps other opioids he is allowed to be prescribed in the state of NY. 