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04:43:15','',0,'https://anrclinic.nirazo.me/nf_sub/6634/',0,'nf_sub','',0),(6635,0,'2020-09-24 04:26:04','2020-09-24 08:26:04','','','','publish','closed','closed','','6635','','','2020-09-24 04:26:04','2020-09-24 08:26:04','',0,'https://anrclinic.nirazo.me/nf_sub/6635/',0,'nf_sub','',0),(6636,0,'2020-09-24 05:26:21','2020-09-24 09:26:21','','','','publish','closed','closed','','6636','','','2020-09-24 05:26:21','2020-09-24 09:26:21','',0,'https://anrclinic.nirazo.me/nf_sub/6636/',0,'nf_sub','',0),(6644,2,'2020-09-24 09:33:09','2020-09-24 13:33:09','<ul>\n							<li>\n					<a href=\"tel:+18137507470\">					Give Us a Call\n											</a>\n									</li>\n						</ul>\n					<ul>\n							<li>\n					<a href=\"tel:+18137507470\">						\n										(813) 750-7470\n											</a>\n									</li>\n						</ul>\n					<ul>\n							<li>\n					<a href=\"mailto:contact@anrclinicus.com\">					Send us a Message\n											</a>\n									</li>\n						</ul>\n					<ul>\n							<li>\n					<a href=\"mailto:contact@anrclinicus.com\">						\n										contact@anrclinicus.com\n											</a>\n									</li>\n						</ul>\n			<a href=\"https://anrclinic.nirazo.me/contact/\" role=\"button\">\n						Schedule Your Free Consultation\n					</a>\n			<h1>Methadone</h1>		\n			<h3>pronounced as (meth\' a done)\n</h3>		\n		<p>A synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of morphine and morphine-like agents. The characteristic morphine-like effects include analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. However, the detoxification symptoms between morphine-like agents and methadone differ in that the onset of methadone\'s withdrawal symptoms is slower, the course is more prolonged and the symptoms are less severe.<br>\nMethadone, sold under the brand name Dolophine among others, is an opioid used for opioid maintenance therapy in opioid dependence and for chronic pain management. Detoxification using methadone can be accomplished in less than a month, or it may be done gradually over as long as six months. Wikipedia&nbsp;</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:5pt;margin-bottom:0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+formula&amp;stick=H4sIAAAAAAAAAOPgE-LQz9U3MLVIL9RSz0620k_OSM3NLC4pqoSwkhNz4pPzcwvyS_NSrNLyi3JLcxIXsQrmppZkJKbk56UqQMUABDWXhUkAAAA&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBnegQIDxAC\" style=\"text-decoration:none;\">Formula</a>: C21H27NO</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:5pt 0pt 0pt 0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+onset+of+action&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBoegQIEBAC\" style=\"text-decoration:none;\">Onset of action</a>: Rapid</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:5pt 0pt 0pt 0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+metabolism&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBpegQIEhAC\" style=\"text-decoration:none;\">Metabolism</a>: Liver (<a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=CYP3A4&amp;stick=H4sIAAAAAAAAAONgVuLUz9U3MI63yM1ZxMrmHBlg7GgCAE2dvTgWAAAA&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQmxMoATBpegQIEhAD\" style=\"text-decoration:none;\">CYP3A4</a>, <a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=CYP2B6&amp;stick=H4sIAAAAAAAAAONgVuLSz9U3MCpMKchLWsTK5hwZYORkBgAmNXGVFwAAAA&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQmxMoAjBpegQIEhAE\" style=\"text-decoration:none;\">CYP2B6</a> and CYP2D6-mediated)</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:5pt 0pt 0pt 0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+elimination+half-life&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBqegQIERAC\" style=\"text-decoration:none;\">Elimination half-life</a>: 15 to 55 hours</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:5pt 0pt 0pt 0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+excretion&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBregQIFRAC\" style=\"text-decoration:none;\">Excretion</a>: Urine, faeces</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:5pt 0pt 0pt 0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+addiction+liability&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBsegQIGBAC\" style=\"text-decoration:none;\">Addiction liability</a>: <a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=High&amp;stick=H4sIAAAAAAAAAONgVuLSz9U3MCowNMjKXsTK4pGZngEA-1rlpxUAAAA&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQmxMoATBsegQIGBAD\" style=\"text-decoration:none;\">High</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:5pt 0pt 0pt 0pt;\"><a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=methadone+bioavailability&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQ6BMoADBtegQIFhAC\" style=\"text-decoration:none;\">Bioavailability</a>: 15-20% subcutaneous; 100% <a href=\"https://www.google.com/search?sxsrf=ALeKk03zI2sHAYOGw_2_lgDDcm85ZXFOkQ:1599651790821&amp;q=intravenous&amp;stick=H4sIAAAAAAAAAONgVuLUz9U3MLRIjrdYxMqdmVdSlFiWmpdfWgwAXduzmRsAAAA&amp;sa=X&amp;ved=2ahUKEwi46oWm_9vrAhUSNOwKHZVYD-EQmxMoATBtegQIFhAD\" style=\"text-decoration:none;\">intravenous</a>; 41–99% (by mouth)</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:3pt 0pt 3pt 0pt;\">Common brands: Diskets, Methadone Intensol, Methadose</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 4pt 0pt;\">Narcotic</p><p dir=\"ltr\" style=\"line-height:1.7142857142857142;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">It can treat moderate to severe pain. It can also treat narcotic drug addiction.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">Brands: Diskets, Methadone Intensol, Methadose, and Dolophine</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">Availability: Prescription needed</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">Pregnancy: Consult a doctor</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">Alcohol: Avoid. Very serious interactions can occur</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">Drug class: Opioid</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\">&nbsp;</p><p dir=\"ltr\" style=\"line-height:1.7999999999999998;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:3pt 0pt 0pt 0pt;\">Methadone is a synthetic opioid with analgesic activity. Methadone mimics the actions of endogenous peptides at CNS opioid receptors, primarily on the mu-receptor and has actions similar to those of <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/morphine\" style=\"text-decoration:none;\">morphine</a> and <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/morphine\" style=\"text-decoration:none;\">morphine</a>-like agents. The characteristic <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/morphine\" style=\"text-decoration:none;\">morphine</a>-like effects include analgesia, euphoria, sedation, respiratory depression, miosis, bradycardia and physical dependence. However, the detoxification symptoms between <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/morphine\" style=\"text-decoration:none;\">morphine</a>-like agents and methadone differ in that the onset of methadone\'s withdrawal symptoms is slower, the course is more prolonged and the symptoms are less severe.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:6pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;\">NCI Thesaurus (NCIt)</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Source: <a href=\"https://pubchem.ncbi.nlm.nih.gov/source/NCI%20Thesaurus%20(NCIt)\" style=\"text-decoration:none;\">NCI Thesaurus (NCIt)</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Record Name: Methadone</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">URL: <a href=\"https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&amp;ns=NCI_Thesaurus&amp;code=C62044\" style=\"text-decoration:none;\">https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&amp;ns=NCI_Thesaurus&amp;code=C62044</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Description: NCI Thesaurus (NCIt) provides reference terminology for many systems. It covers vocabulary for clinical care, translational and basic research, and public information and administrative activities.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">License Note: Unless otherwise indicated, all text within NCI products is free of copyright and may be reused without our permission. Credit the National Cancer Institute as the source.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:12pt;padding:-6pt 0pt 0pt 0pt;\">License URL: <a href=\"https://www.cancer.gov/policies/copyright-reuse\" style=\"text-decoration:none;\">https://www.cancer.gov/policies/copyright-reuse</a></p><p dir=\"ltr\" style=\"line-height:1.7999999999999998;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:3pt 0pt 0pt 0pt;\">Methadone is a DEA controlled drug and a DEA Schedule II controlled substance. Substances in the DEA Schedule II have a high potential for abuse which may lead to severe psychological or physical dependence. Methadone is classified by the DEA as a Narcotics (Opioids) drug. Street names for Methadone are Amidone, Chocolate Chip Cookies, Fizzies, Maria, Pastora, Salvia, Street Methadone, and <a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/Water\" style=\"text-decoration:none;\">Water</a>.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:6pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;\">Drug Enforcement Administration (DEA)</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Source: <a href=\"https://pubchem.ncbi.nlm.nih.gov/source/Drug%20Enforcement%20Administration%20(DEA)\" style=\"text-decoration:none;\">Drug Enforcement Administration (DEA)</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Record Name: Methadone</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">URL: <a href=\"https://www.dea.gov/factsheets\" style=\"text-decoration:none;\">https://www.dea.gov/factsheets</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Description: The U.S. Drug Enforcement Administration (DEA) enforces the controlled substances laws and regulations of the United States and brings to the criminal and civil justice system of the United States, or any other competent jurisdiction, those organizations and principal members of organizations, involved in the growing, manufacture, or distribution of controlled substances appearing in or destined for illicit traffic in the United States; and to recommend and support non-enforcement programs aimed at reducing the availability of illicit controlled substances on the domestic and international markets.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">License Note: Unless otherwise indicated, information on Department of Justice websites is in the public domain and may be copied and distributed without permission. Citation of the Department of Justice as source of the information is appreciated, as appropriate.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:12pt;padding:-6pt 0pt 0pt 0pt;\">License URL: <a href=\"https://www.justice.gov/legalpolicies\" style=\"text-decoration:none;\">https://www.justice.gov/legalpolicies</a></p><p dir=\"ltr\" style=\"line-height:1.7999999999999998;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:3pt 0pt 0pt 0pt;\">Methadone is a synthetic opioid which is used widely as an analgesic as well as maintenance therapy for persons with opioid dependency. Patients on chronic methadone therapy for opioid dependency often have underlying chronic viral hepatitis, but methadone itself has not been linked to serum enzyme elevations during therapy or to clinically apparent liver injury.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:6pt;margin-bottom:0pt;padding:0pt 0pt 12pt 0pt;\">LiverTox</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Source: <a href=\"https://pubchem.ncbi.nlm.nih.gov/source/LiverTox\" style=\"text-decoration:none;\">LiverTox</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Record Name: Methadone</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">URL: <a href=\"https://www.ncbi.nlm.nih.gov/books/n/livertox/Methadone/\" style=\"text-decoration:none;\">https://www.ncbi.nlm.nih.gov/books/n/livertox/Methadone/</a></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:-6pt 0pt 12pt 0pt;\">Description: LIVERTOX provides up-to-date, accurate, and easily accessed information on the diagnosis, cause, frequency, patterns, and management of liver injury attributable to prescription and nonprescription medications, herbals and dietary supplements.</p><p></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:12pt;padding:-6pt 0pt 0pt 0pt;\">License URL: <a href=\"https://www.nlm.nih.gov/copyright.html\" style=\"text-decoration:none;\">https://www.nlm.nih.gov/copyright.html</a>  </p>		\n			<h2>Compound Summary</h2>		\n		<p></p>\n<h3 dir=\"ltr\" style=\"line-height: 1.38; margin-top: 16pt; margin-bottom: 4pt;\"><img src=\"https://lh5.googleusercontent.com/mCwuenLwZhdITw29zN464TuWMv7mB8pWHOgJSXhZaeu1Bbot-8lFAibEnWgYC7WwjUKjJIsNYp9UgxS5gxKUpExuwxtPAjSASv57fL1ehXpWE6spFPgVnpm803iAGegiLuEEaSun\" width=\"300\" height=\"300\" style=\"margin-left:0px;margin-top:0px;\"><br></h3>\n<h3 dir=\"ltr\" style=\"line-height: 1.38; margin-top: 16pt; margin-bottom: 4pt;\">2D structure (<a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/4095#section=2D-Structure\" style=\"font-size: 15px; font-weight: normal; font-family: &quot;Roboto Condensed&quot;, &quot;Roboto Condensed&quot;; background-color: rgb(255, 255, 255);\">source</a>)</h3><p></p>\n<h3 dir=\"ltr\" style=\"line-height: 1.38; margin-top: 16pt; margin-bottom: 4pt;\"><img src=\"https://lh5.googleusercontent.com/GKNtERZMe_metD_BeFIGalehSagwHgvHaLBeQHcV1VoOAnfhtX9kVclfMlqbDUGKuyMbudg0AxYL8fxpBGof5b0B-86mDHWMepYnLBLPMpoSBhGmRanaWjtVgztPnJVSQMPWfyKN\" width=\"395\" height=\"296\" style=\"margin-left:0px;margin-top:0px;\"><br></h3>\n<h3 dir=\"ltr\" style=\"line-height: 1.38; margin-top: 16pt; margin-bottom: 4pt;\">3D Conformer (<a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/4095#section=3D-Conformer\" style=\"font-size: 15px; font-weight: normal; font-family: &quot;Roboto Condensed&quot;, &quot;Roboto Condensed&quot;; background-color: rgb(255, 255, 255);\">source</a>)</h3>		\n			<h2>Synonyms - MeSH Entry Terms\n</h2>		\n		<ol style=\"margin-top:0;margin-bottom:0;\"><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Amidone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Biodone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Dolophine</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Hydrochloride, Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadol</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metasedin</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methaddict</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadone Hydrochloride</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadose</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methex</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Phenadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Phymet</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Physeptone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Pinadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Symoron</p></li></ol><p></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">(<a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/4095#section=MeSH-Entry-Terms&amp;fullscreen=true\" style=\"text-decoration:none;\">source</a>)</p>		\n			<h2>Depositor-Supplied Synonyms</h2>		\n		<ol style=\"margin-top:0;margin-bottom:0;\"><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">dl-Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Dolophine</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Phenadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Amidone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Adanon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Diaminon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Dolophin</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Ketalgin</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Physeptone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Algovetin</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Heptadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Heptanon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Sedo-Rapide</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">76-99-3</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Racemic methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Amidon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(+-)-Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(+/-)-Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6-(dimethylamino)-4,4-diphenylheptan-3-one</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadonum</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Heptanon (pharmaceutical)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadone [DCIT]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadona [Spanish]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadonum [Latin]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadona [Spanish]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">l-Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadone [INN:BAN]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6-Dimethylamino-4,4-diphenyl-3-heptanone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadona [INN-Spanish]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadonum [INN-Latin]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metasedin</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Polamivet</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Hoechst 10820</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Dolophine HCL</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(RS)-methadones</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Althose</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Eptadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Symoron</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">HSDB 3119</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">K 174</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">AN 148</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">EINECS 200-996-9</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">A 4624</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">BRN 3213669</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">rac-Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">CHEBI:6807</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">DEA No. 9250</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(+/-)-Methadone hydrochloride</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadona</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadona</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6-(Dimethylamino)-4,4-diphenyl-3-heptanone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Levometadona [INN-Spanish]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Levomethadonum [INN-Latin]</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">UNII-UC6VBE7V1Z</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadone (BAN)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(R)-6-(Dimethylamino)-4,4-diphenyl-3-hetpanone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">3-14-00-00279 (Beilstein Handbook Reference)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Fenadone (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Heptanon (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Dolophine (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Heptadone (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Levomethadon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Phenadone (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Metadon</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">UC6VBE7V1Z</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">AN-148 (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">BRN 3213667</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">BRN 3213668</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(plusmn)-methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">PHY</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Hoescht 10820 (*Hydrochloride*)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Mecodin (Salt/Mix)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Methadone-HCL,(-)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Polamidon (Salt/Mix)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Polamidone (Salt/Mix)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(.+/-.)-Methadone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">CHEMBL651</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">SCHEMBL34140</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">3-HEPTANONE, 6-(DIMETHYLAMINO)-4,4-DIPHENYL-, (S)-</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">DivK1c_000963</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">GTPL5458</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">IDS-NM-002</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Adanon hydrochloride (Salt/Mix)</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">DTXSID7023273</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">BDBM82507</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">KBio1_000963</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">NINDS_000963</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">NSC_22266</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">STL455106</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">AKOS015962259</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">rac-Methadone 0.1 mg/ml in Methanol</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">rac-Methadone 1.0 mg/ml in Methanol</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">DB00333</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">IDI1_000963</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">NCGC00248116-01</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">NCGC00248116-02</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">297-88-1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">AC-16055</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">LS-74485</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">LS-74486</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">LS-74487</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">SC-54552</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">2-Dimethylamino-4,4-diphenyl-5-heptanone</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">CAS_5967-73-7</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">DB-053574</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6-(dimethylamino)-4,4-diphenyl-heptan-3-one</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP1441224A2</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2275420A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2277875A2</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2280008A2</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2298764A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2298765A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2298776A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2305654A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2308509A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2308872A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">6481-EP2316829A1</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">C07163</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">D08195</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">L000874</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Q179996</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">3-Hetpanone, 6-(dimethylamino)-4,4-diphenyl-, (R)-</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">3-Heptanone, 6-(dimethylamino)-4,4-diphenyl-, (.+/-.)-</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">DL-6-DIMETHYLAMINO-4,4-DIPHENYL-3-HEPTANONE-1,1,1-</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(+/-)-Methadone solution, 1 mg/mL in methanol, ampule of 1 mL, certified reference material</p></li><li dir=\"ltr\" style=\"list-style-type:decimal;font-size:11pt;font-family:Arial;color:#000000;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">(+/-)-Methadone solution, 100 mug/mL in methanol, ampule of 1 mL, certified reference material</p></li></ol><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">(<a href=\"https://pubchem.ncbi.nlm.nih.gov/compound/4095#section=Depositor-Supplied-Synonyms&amp;fullscreen=true\" style=\"text-decoration:none;\">source</a>)</p><p><br></p>		\n			<h2>Methadone Interactions</h2>		\n		<p><img src=\"https://lh6.googleusercontent.com/A9LUIubIext_q4zZuHMuf2pdeppIYZmAsAuA9ap_L9g40dct26CHQEYu7yMB3CbwOtiSynFUgMdrPmpgkOZogGocKltfNdCKKcciWtsjsfRcnCmO2NTFYzI1veR9Qn8ywUv5Kb8A\" width=\"240\" height=\"160\" style=\"margin-left:0px;margin-top:0px;\"><br></p>\n<p></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Using methadone with other opioids is extremely dangerous. For instance, a methadone and oxycodone interaction can increase the risk of respiratory depression, hypotension, coma, overdose and death. The same is true for mixing methadone and hydrocodone, heroin or any other known opiates. (<a href=\"https://www.medprotreatmentcenters.com/methadone-interaction-with-other-drugs/#:~:text=Using%20methadone%20with%20other%20opioids,or%20any%20other%20known%20opiates.\" style=\"text-decoration:none;\">source</a>)</p>		\n			<h2>Important Warning</h2>		\n		<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Methadone may be habit forming. Take methadone exactly as directed. Do not take a larger dose, take it more often, or take it for a longer period of time or in a different way than prescribed by your doctor. While taking methadone, discuss with your healthcare provider your pain treatment goals, length of treatment, and other ways to manage your pain. Tell your doctor if you or anyone in your family drinks or has ever drunk large amounts of alcohol, uses or has ever used street drugs, or has overused prescription medications, or if you have or have ever had depression or another mental illness. There is a greater risk that you will overuse methadone if you have or have ever had any of these conditions. Talk to your healthcare provider immediately and ask for guidance if you think that you have an opioid addiction or call the U.S. Substance Abuse and Mental Health Services Administration (SAMHSA) National Helpline at 1-800-662-HELP.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Methadone may cause serious or life-threatening breathing problems, especially during the first 24 to 72 hours of your treatment and any time your dose is increased. Your doctor will monitor you carefully during your treatment. Tell your doctor if you have or have ever had slowed breathing or asthma. Your doctor will probably tell you not to take methadone. Also tell your doctor if you have or have ever had lung disease such as chronic obstructive pulmonary disease (COPD; a group of lung diseases that includes chronic bronchitis and emphysema), a head injury, or any condition that increases the amount of pressure in your brain. The risk that you will develop breathing problems may be higher if you are an older adult or are weak or malnourished due to disease. If you experience any of the following symptoms, call your doctor immediately or get emergency medical treatment: slowed breathing, long pauses between breaths, or shortness of breath.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Taking certain other medications during your treatment with methadone may increase the risk that you will experience serious, life-threatening side effects such as breathing problems, sedation, or coma. Tell your doctor if you are taking or plan to take any of the following medications: antipsychotics such as aripiprazole (Abilify), asenapine (Saphris), cariprazine (Vraylar), chlorpromazine, clozapine (Versacloz), fluphenazine, haloperidol (Haldol), iloperidone (Fanapt), loxapine, lurasidone (Latuda), molindone, olanzapine (Zyprexa), paliperidone (Invega), perphenazine, pimavanserin (Nuplazid), quetiapine (Seroquel), risperidone (Risperdal), thioridazine, thiothixene, trifluoperazine, and ziprasidone (Geodon); benzodiazepines such as alprazolam (Xanax), chlordiazepoxide (Librium), clonazepam (Klonopin), clorazepate (Gen-Xene, Tranxene), diazepam (Diastat, Valium), estazolam, flurazepam, lorazepam (Ativan), oxazepam, temazepam (Restoril), and triazolam (Halcion); opiate (narcotic) medications for pain and cough; medications for nausea or mental illness; muscle relaxants; sedatives; sleeping pills; or tranquilizers. Your doctor may need to change the doses of your medications and will monitor you carefully. If you take methadone with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. Be sure that your caregiver or family members know which symptoms may be serious so they can call the doctor or emergency medical care if you are unable to seek treatment on your own.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Drinking alcohol, taking prescription or nonprescription medications that contain alcohol, or using street drugs during your treatment with methadone increases the risk that you will experience serious, life-threatening side effects. Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Do not allow anyone else to take your medication. Methadone may harm or cause death to other people who take your medication, especially children. Store methadone in a safe place so that no one else can take it accidentally or on purpose. Be especially careful to keep methadone out of the reach of children. Keep track of how many tablets or how much liquid is left so you will know if any medication is missing. Dispose of any unwanted methadone tablets or oral solution properly according to instructions. (See STORAGE and DISPOSAL.)</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Methadone may cause a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting, or sudden death). Tell your doctor if you or anyone in your family has or has ever had long QT syndrome; or if you have or ever had a slow or irregular heartbeat; low blood levels of potassium or magnesium, or heart disease. Tell your doctor and pharmacist if you are taking or plan to take any of the following medications: antidepressants such as amitriptyline, amoxapine, clomipramine (Anafranil), desipramine (Norpramin), doxepin (Silenor), imipramine (Tofranil), nortriptyline (Pamelor), protriptyline (Vivactil), and trimipramine (Surmontil); certain antifungals such as fluconazole (Diflucan), itraconazole (Onmel, Sporanox), ketoconazole, and voriconazole (Vfend); diuretics (\'water pills\'); erythromycin (Eryc, Erythrocin, others); fludrocortisone; certain laxatives; medications for irregular heartbeat such as amiodarone (Nexterone, Pacerone), disopyramide (Norpace), dofetilide (Tikosyn), flecainide, ibutilide (Corvert), procainamide, and quinidine (in Nuedexta); nicardipine (Cardene); and risperidone (Risperdal); and sertraline (Zoloft). If you experience any of the following symptoms, call your doctor immediately: pounding heartbeat, dizziness, lightheadedness, or fainting.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Tell your doctor if you are pregnant or plan to become pregnant. If you take methadone regularly during your pregnancy, your baby may experience life-threatening withdrawal symptoms after birth. Tell your baby\'s doctor right away if your baby experiences any of the following symptoms: irritability, hyperactivity, abnormal sleep, high-pitched cry, uncontrollable shaking of a part of the body, vomiting, diarrhea, or failure to gain weight.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Talk to your doctor about the risks of taking methadone for your condition.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Your doctor or pharmacist will give you the manufacturer\'s patient information sheet (Medication Guide) when you begin treatment with methadone and each time you fill your prescription if a Medication Guide is available for the methadone product you are taking. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit the Food and Drug Administration (FDA) website (<a href=\"http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm\" style=\"text-decoration:none;\">http://www.fda.gov/Drugs/DrugSafety/ucm085729.htm</a>) or the manufacturer\'s website to obtain the Medication Guide.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Use of methadone to treat opiate addiction:</p><p></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:15pt;\">If you have been addicted to an opiate (narcotic drug such as heroin), and you are taking methadone to help you stop taking or continue not taking the drug, you must enroll in a treatment program. The treatment program must be approved by the state and federal governments and must treat patients according to specific federal laws. You may have to take your medication at the treatment program facility under the supervision of the program staff. Ask your doctor or the treatment program staff if you have any questions about enrolling in the program or taking or getting your medication. </p>		\n			<h2>What side effects can this medication cause?</h2>		\n		<h3 dir=\"ltr\" style=\"line-height:1.482;background-color:#ffffff;margin-top:0pt;margin-bottom:6pt;\">Methadone may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:</h3><ul style=\"margin-top:0;margin-bottom:0;\"><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">headache</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">weight gain</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">stomach pain</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">dry mouth</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">sore tongue</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">flushing</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">difficulty urinating</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">mood changes</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">vision problems</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:39pt;\" role=\"presentation\">difficulty falling asleep or staying asleep</p></li></ul><h3 dir=\"ltr\" style=\"line-height:1.482;background-color:#ffffff;margin-top:0pt;margin-bottom:6pt;\">Some side effects can be serious. If you experience any of the following symptoms or those mentioned in the IMPORTANT WARNING section, call your doctor immediately or get emergency medical help:</h3><ul style=\"margin-top:0;margin-bottom:0;\"><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">seizures</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">itching</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">hives</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">rash</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">swelling of the eyes, face, mouth, tongue, or throat</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">hoarseness</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">difficulty breathing or swallowing</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">extreme drowsiness</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">agitation, hallucinations (seeing things or hearing voices that do not exist), fever, sweating, confusion, fast heartbeat, shivering, severe muscle stiffness or twitching, loss of coordination, nausea, vomiting, or diarrhea</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">nausea, vomiting, loss of appetite, weakness, or dizziness</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">inability to get or keep an erection</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">irregular menstruation</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:39pt;\" role=\"presentation\">decreased sexual desire</p></li></ul><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Methadone may cause other side effects. Call your doctor if you have any unusual problems while you are taking this medication.</p><h3 dir=\"ltr\" style=\"line-height:1.8666720000000003;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">In case of emergency/overdose</h3><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">In case of overdose, call the poison control helpline at 1-800-222-1222. Information is also available online at <a href=\"https://www.poisonhelp.org/help\" style=\"text-decoration:none;\">https://www.poisonhelp.org/help</a>. If the victim has collapsed, had a seizure, has trouble breathing, or can\'t be awakened, immediately call emergency services at 911.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">While you are taking methadone, you may be told to always have a rescue medication called naloxone available (e.g., home, office). Naloxone is used to reverse the life-threatening effects of an overdose. It works by blocking the effects of opiates to relieve dangerous symptoms caused by high levels of opiates in the blood. You will probably be unable to treat yourself if you experience an opiate overdose. You should make sure that your family members, caregivers, or the people who spend time with you know how to tell if you are experiencing an overdose, how to use naloxone, and what to do until emergency medical help arrives. Your doctor or pharmacist will show you and your family members how to use the medication. Ask your pharmacist for the instructions or visit the manufacturer\'s website to get the instructions. If someone sees that you are experiencing symptoms of an overdose, he or she should give you your first dose of naloxone, call 911 immediately, and stay with you and watch you closely until emergency medical help arrives. Your symptoms may return within a few minutes after you receive naloxone. If your symptoms return, the person should give you another dose of naloxone. Additional doses may be given every 2 to 3 minutes, if symptoms return before medical help arrives.</p><h3 dir=\"ltr\" style=\"line-height:1.482;background-color:#ffffff;margin-top:0pt;margin-bottom:6pt;\">Symptoms of overdose may include the following:</h3><ul style=\"margin-top:0;margin-bottom:0;\"><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">small, pinpoint pupils (black circles in the center of the eyes)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">slow or shallow breathing</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">drowsiness</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">cool, clammy, or blue skin</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">loss of consciousness (coma)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:10.5pt;font-family:Arial;color:#444444;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;margin-left: 15pt;\"><p dir=\"ltr\" style=\"line-height:1.542852;background-color:#ffffff;margin-top:0pt;margin-bottom:39pt;\" role=\"presentation\">limp muscles</p></li></ul><h3 dir=\"ltr\" style=\"line-height:1.8666720000000003;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">What other information should I know?</h3><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Keep all appointments with your doctor or clinic. Your doctor may order certain lab tests to check your response to methadone.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">Before having any laboratory test (especially those that involve methylene blue), tell your doctor and the laboratory personnel that you are taking methadone.</p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 15pt 0pt;\">This prescription is not refillable. If you continue to experience pain after you finish taking the methadone, call your doctor. If you take this medication on a regular basis, be sure to schedule appointments with your doctor so that you do not run out of medication.</p><p></p><p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:15pt;\">It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.<br>(<a href=\"https://medlineplus.gov/druginfo/meds/a682134.html\" style=\"text-decoration:none;\">source</a>) </p>		\n			<h2>LABEL: methadone- methadone hydrochloride injection, solution</h2>		\n		<h3 dir=\"ltr\" style=\"line-height:1.38;margin-top:16pt;margin-bottom:4pt;\">Description:</h3>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">Methadone Hydrochloride Injection, USP, 10 mg/mL is an opioid analgesic.</p>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">Each milliliter of Methadone Hydrochloride Injection contains 10 mg (0.029 mmol) of methadone hydrochloride, equivalent to 8.95 mg of methadone free base.</p>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">Methadone hydrochloride is a white, crystalline material that is water-soluble.</p>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">Methadone hydrochloride is chemically described as 6-(dimethylamino)-4,4-diphenyl-3-hepatanone hydrochloride. Its molecular formula is C21H27NO•HCl and it has a molecular weight of 345.91. Methadone hydrochloride has a melting point of 235° C, and a pKa of 8.25 in water at 20°C. Its octanol/water partition coefficient at pH 7.4 is 117. A solution (1:100) in water has a pH between 4.5 and 6.5.</p>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">It has the following structural formula:</p>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;\"><img alt=\"Image from Drug Label Content\" src=\"https://lh6.googleusercontent.com/U6_SKzWyTXn0f4ELJJvxpgisEW68Z4znrbVScoZz1ZyjhcYS7h3Fz3p7PnjU3lcEWXRmJY5opPIevqIzYfJgnuwYB99ChrIls2oUv-_A5y-Tp6zaf9LjGclhYaoYvEO-800HLTvR\" width=\"85\" height=\"44\" style=\"margin-left:0px;margin-top:0px;\"></p>\n<p dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:0pt 0pt 8pt 0pt;\">Methadone Hydrochloride Injection is a sterile injectable solution containing the following inactive ingredients: chlorobutanol, 0.5%, as a preservative, and sodium chloride. The pH of the sterile injectable solution may have been adjusted during manufacturing with sodium hydroxide and/or hydrochloric acid.</p>\n<h3 dir=\"ltr\" style=\"line-height:1.38;margin-top:16pt;margin-bottom:4pt;\">Indication and usage</h3>\n<p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">For the treatment of moderate to severe pain not responsive to non-narcotic analgesics.</p>\n<p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">For use in temporary treatment of opioid dependence in patients unable to take oral medication.</p>\n<p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Outpatient maintenance and outpatient detoxification treatment may be provided only by opioid treatment programs (OTPs) certified by the Federal Substance Abuse and Mental Health Services Administration (SAMHSA) and registered by the Drug Enforcement Administration (DEA). This does not preclude the maintenance treatment of a patient with concurrent opioid addiction who is hospitalized for conditions other than opioid addiction and who requires temporary maintenance during the critical period of hospitalization, or of a patient whose enrollment has been verified in a program which has been certified for maintenance treatment with methadone.</p>\n<p><b style=\"font-weight:normal;\"><br></b></p>\n<p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">NOTE: INJECTABLE METHADONE PRODUCTS ARE NOT APPROVED FOR THE OUTPATIENT TREATMENT OF OPIOID DEPENDENCE. IN THIS PATIENT POPULATION, PARENTERAL METHADONE IS TO BE USED ONLY FOR PATIENTS UNABLE TO TAKE ORAL MEDICATION, SUCH AS HOSPITALIZED PATIENTS</p>\n<h3 dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:16pt;margin-bottom:0pt;padding:2.4492225pt 2.4492225pt 12.4492225pt 0pt;\">Drug abuse and dependence</h3>\n<h3 dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:8.4492225pt 2.4492225pt 12.4492225pt 0pt;\">Methadone is a μ-agonist opioid with an abuse liability similar to that of morphine and is a Schedule II controlled substance. Methadone, like morphine and other opioids used for analgesia, has the potential for being abused and is subject to criminal diversion.</h3>\n<h4 dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:6.449222499999999pt 2.4492225pt 12.4492225pt 0pt;\">Abuse<br>Drug addiction is characterized by a preoccupation with the procurement, hoarding, and abuse of drugs for non-medicinal purposes. Drug addiction is treatable, utilizing a multi-disciplinary approach, but relapse is common.<br>“Drug seeking” behavior is very common to addicts and drug abusers. Drug seeking tactics include emergency calls or visits near the end of the office hours, refusal to undergo appropriate examination, testing or referral, repeated claims of loss of prescriptions, tampering with prescriptions and reluctance to provide prior medical records or contact information for other treating physician(s). Doctor shopping (visiting multiple prescribers) to obtain additional prescriptions is common among drug abusers and people suffering from untreated addictions.<br><br></h4>\n<h4 dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:6.449222499999999pt 2.4492225pt 12.4492225pt 0pt;\">Physical Dependence and Tolerance<br>Abuse and addiction are separate and distinct from physical dependence and tolerance. Physicians should be aware that addiction may not be accompanied by concurrent tolerance and symptoms of physical dependence in all addicts. In addition, abuse of opioids can occur in the absence of true addiction and is characterized by misuse for non-medical purposes, often in combination with other psychoactive substances. Methadone Hydrochloride Injection, like other opioids, may be diverted for non-medical use. Careful record-keeping of prescribing information, including quantity, frequency, and renewal requests is strongly advised.</h4>\n<h4 dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:0pt;padding:6.449222499999999pt 2.4492225pt 12.4492225pt 0pt;\"><br>Abuse of Methadone Hydrochloride Injection poses a risk of overdose and death. This risk is increased with concurrent abuse of Methadone Hydrochloride Injection with alcohol and other substances. In addition, parenteral drug abuse is commonly associated with transmission of infectious disease such as hepatitis and HIV.</h4>\n<p></p>\n<h4 dir=\"ltr\" style=\"line-height:1.38;background-color:#ffffff;margin-top:0pt;margin-bottom:10pt;padding:6.449222499999999pt 2.4492225pt 2.4492225pt 0pt;\">Proper assessment of the patient, proper prescribing practices, periodic re-evaluation of therapy, and proper dispensing and storage are appropriate measures that help to limit abuse of opioid drugs.<br>Infants born to mothers physically dependent on opioids may also be physically dependent and may exhibit respiratory difficulties and withdrawal symptoms.<br>(<a href=\"https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=9bbe219f-3bf1-44f4-a709-cd108c4fa9ef\" style=\"text-decoration:none;\">source</a>)</h4>		\n			<h2>In the news</h2>		\n		<p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Middletown methadone clinic proposal draws mixed reaction</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\"><a href=\"https://www.middletownpress.com/middletown/article/Middletown-methadone-clinic-proposal-draws-mixed-15544109.php\" style=\"text-decoration:none;\">https://www.middletownpress.com/middletown/article/Middletown-methadone-clinic-proposal-draws-mixed-15544109.php</a></p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Covid-19 has freed opioid addiction patients from daily methadone clinic visits</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\"><a href=\"https://qz.com/1889461/covid-19-has-forced-a-relaxation-of-methadone-rules/\" style=\"text-decoration:none;\">https://qz.com/1889461/covid-19-has-forced-a-relaxation-of-methadone-rules/</a></p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Study: Methadone Dosing Needs to be More Precise</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\"><a href=\"https://ubmd.com/about-ubmd/news.host.html/content/shared/smbs/news/2020/08/talal-methadone-dosing-11360.detail.html\" style=\"text-decoration:none;\">https://ubmd.com/about-ubmd/news.host.html/content/shared/smbs/news/2020/08/talal-methadone-dosing-11360.detail.html</a></p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Methadone Patients’ Data Poised to Be Entered Into PDMPs</p><p></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\"><a href=\"https://filtermag.org/methadone-patients-prescription-drug-monitoring/\" style=\"text-decoration:none;\">https://filtermag.org/methadone-patients-prescription-drug-monitoring/</a></p>		\n			<h2>Methadone FAQ</h2>		\n		<p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Does methadone mess with your heart?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">The main cardiac effects of methadone include prolongation of QT interval and torsade de pointes. Other effects include changes in QT dispersion, pathological U waves, Taku-Tsubo syndrome (stress cardiomyopathy), Brugada-like syndrome, and coronary artery diseases.</p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">How often can you take methadone?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">When methadone is used to relieve pain, it may be taken every 8 to 12 hours. If you take methadone as part of a treatment program, your doctor will prescribe the dosing schedule that is best for you.</p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">What foods interact with methadone?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Grapefruit juice can increase the blood levels and effects of methadone. If you regularly consume grapefruits or grapefruit juice, you should be monitored for side effects and/or changes in methadone levels. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.</p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">What anxiety medicine is safe to take with methadone?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">If you have anxiety while taking methadone, you have options for reducing your symptoms.</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Benzodiazepine medications for anxiety include:</p><ul style=\"margin-top:0;margin-bottom:0;\"><li dir=\"ltr\" style=\"list-style-type:disc;font-size:12pt;font-family:Arial;color:#222222;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Alprazolam (Xanax®)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:12pt;font-family:Arial;color:#222222;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Diazepam (Valium®)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:12pt;font-family:Arial;color:#222222;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Clonazepam (Klonopin®)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:12pt;font-family:Arial;color:#222222;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Lorazepam (Ativan®)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:12pt;font-family:Arial;color:#222222;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Chlordiazepoxide (Librium®)</p></li><li dir=\"ltr\" style=\"list-style-type:disc;font-size:12pt;font-family:Arial;color:#222222;background-color:transparent;font-weight:400;font-style:normal;font-variant:normal;text-decoration:none;vertical-align:baseline;white-space:pre;\"><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\" role=\"presentation\">Oxazepam (Serax®)</p></li></ul><p><b style=\"font-weight:normal;\"><br><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">What should you not take with methadone?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Using methadone with other opioids is extremely dangerous. For instance, a methadone and oxycodone interaction can increase the risk of respiratory depression, hypotension, coma, overdose and death. The same is true for mixing methadone and hydrocodone, heroin or any other known opiates.</p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">How often can you take methadone?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">When methadone is used to relieve pain, it may be taken every 8 to 12 hours. If you take methadone as part of a treatment program, your doctor will prescribe the dosing schedule that is best for you.</p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">What medications interact with methadone?</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Moderate Interactions</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">LEVOMETHADONE; METHADONE/FLUVOXAMINE.</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">SELECTED OPIOID ANALGESICS/CIMETIDINE.</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">LEVOMETHADONE; METHADONE/POSSIBLE QT PROLONGING AGENTS.</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">LEVOMETHADONE; METHADONE/EFAVIRENZ; NEVIRAPINE.</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">LEVOMETHADONE; METHADONE/NELFINAVIR; RITONAVIR; TELAPREVIR.</p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">SELECTED OPIOIDS/PHENOBARBITAL; PRIMIDONE.</p><p><b style=\"font-weight:normal;\"><br></b></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">Does methadone mess with your heart?</p><p></p><p dir=\"ltr\" style=\"line-height:1.38;margin-top:0pt;margin-bottom:0pt;\">The main cardiac effects of methadone include prolongation of QT interval and torsade de pointes. Other effects include changes in QT dispersion, pathological U waves, Taku-Tsubo syndrome (stress cardiomyopathy), Brugada-like syndrome, and coronary artery diseases. </p>		\n			<h3>Quick Navigation</h3>		\n			<h3>Become Opioid Free With ANR</h3>		\n										<img width=\"124\" height=\"153\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Vector.png\" alt=\"\" loading=\"lazy\" />											\n			<h3>Schedule a <orange>FREE</orange> consultation \nwith one of our physicians today\n</h3>		\n			<a href=\"https://anrclinic.nirazo.me/contact/\" role=\"button\">\n						CLICK HERE\n					</a>','wiki page tempalte','','publish','closed','closed','','wiki-page-tempalte','','','2020-09-24 09:33:10','2020-09-24 13:33:10','',0,'https://anrclinic.nirazo.me/?elementor_library=wiki-page-tempalte',0,'elementor_library','',0),(6655,0,'2020-09-24 13:45:55','2020-09-24 17:45:55','','','','publish','closed','closed','','6655','','','2020-09-24 13:45:55','2020-09-24 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17:42:42','',0,'https://anrclinic.nirazo.me/nf_sub/6933/',0,'nf_sub','',0),(6934,0,'2020-10-08 14:35:59','2020-10-08 18:35:59','','','','publish','closed','closed','','6934','','','2020-10-08 14:35:59','2020-10-08 18:35:59','',0,'https://anrclinic.nirazo.me/nf_sub/6934/',0,'nf_sub','',0),(6935,0,'2020-10-08 15:11:46','2020-10-08 19:11:46','','','','publish','closed','closed','','6935','','','2020-10-08 15:11:46','2020-10-08 19:11:46','',0,'https://anrclinic.nirazo.me/nf_sub/6935/',0,'nf_sub','',0),(6936,0,'2020-10-08 15:13:50','2020-10-08 19:13:50','','','','publish','closed','closed','','6936','','','2020-10-08 15:13:50','2020-10-08 19:13:50','',0,'https://anrclinic.nirazo.me/nf_sub/6936/',0,'nf_sub','',0),(6937,0,'2020-10-08 15:15:01','2020-10-08 19:15:01','','','','publish','closed','closed','','6937','','','2020-10-08 15:15:01','2020-10-08 19:15:01','',0,'https://anrclinic.nirazo.me/nf_sub/6937/',0,'nf_sub','',0),(6938,0,'2020-10-08 15:21:39','2020-10-08 19:21:39','','','','publish','closed','closed','','6938','','','2020-10-08 15:21:39','2020-10-08 19:21:39','',0,'https://anrclinic.nirazo.me/nf_sub/6938/',0,'nf_sub','',0),(6939,0,'2020-10-08 15:30:37','2020-10-08 19:30:37','','','','publish','closed','closed','','6939','','','2020-10-08 15:30:37','2020-10-08 19:30:37','',0,'https://anrclinic.nirazo.me/nf_sub/6939/',0,'nf_sub','',0),(6940,0,'2020-10-08 15:31:09','2020-10-08 19:31:09','','','','publish','closed','closed','','6940','','','2020-10-08 15:31:09','2020-10-08 19:31:09','',0,'https://anrclinic.nirazo.me/nf_sub/6940/',0,'nf_sub','',0),(6942,0,'2020-10-08 17:23:55','2020-10-08 21:23:55','','','','publish','closed','closed','','6942','','','2020-10-08 17:23:55','2020-10-08 21:23:55','',0,'https://anrclinic.nirazo.me/nf_sub/6942/',0,'nf_sub','',0),(6943,2,'2020-10-08 17:28:37','2020-10-08 21:28:37','<ul>\n							<li>\n					<a href=\"tel:+18137507470\">					Give Us a Call\n											</a>\n									</li>\n						</ul>\n					<ul>\n							<li>\n					<a href=\"tel:+18137507470\">						\n										(813) 750-7470\n											</a>\n									</li>\n						</ul>\n					<ul>\n							<li>\n					<a href=\"mailto:contact@anrclinicus.com\">					Send us a Message\n											</a>\n									</li>\n						</ul>\n					<ul>\n							<li>\n					<a href=\"mailto:contact@anrclinicus.com\">						\n										contact@anrclinicus.com\n											</a>\n									</li>\n						</ul>\n			<a href=\"https://anrclinic.nirazo.me/contact/\" role=\"button\">\n						Schedule Your Free Consultation\n					</a>\n			<h2>Opioid Dependency & Addiction Treatment</h2>		\n			<h1>Oxycontin Withdrawal Treatment Center \n</h1>		\n			<h2>ANR Clinic is Now in the US</h2>		\n		<p>OxyContin is a brand name for the opioid <a href=\"https://anrclinic.nirazo.me/oxycodone/\" target=\"_blank\" rel=\"noopener noreferrer\">Oxycodone</a>. It comes in tablet form and is sold under many other trade names such as:</p>\n<ul>\n<li>Percodan&nbsp;&nbsp;</li>\n<li>Endodan&nbsp;&nbsp;</li>\n<li>Roxiprin&nbsp;&nbsp;</li>\n<li><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/percocet-withdrawal/\" target=\"_blank\" rel=\"noopener noreferrer\">Percocet</a>&nbsp;</li>\n<li>Endocet&nbsp;&nbsp;</li>\n<li>Roxicet</li>\n</ul>\n<p>OxyContin is one of the most well-known painkiller brands, often prescribed for moderate to severe pain. OxyContin has a high risk of abuse, dependence, and addiction due to the way it acts on the nervous system, even when taken as prescribed.</p>		\n			<h2>OxyContin effects</h2>		\n		<p>OxyContin functions similarly to other opioids by binding with neurochemical transmitters in the central nervous system that inhibit pain signal transmission. It attaches to the same brain receptors as natural endorphins, such as the ones related to feelings of euphoria. With constant and repeated exposure, the brain will very quickly adapt to this increased endorphin production by increasing the number of endorphin receptors.</p><p>When our endorphin levels drop, feelings of depression, pain, and physical cravings occur. The natural balance of receptors and endorphins is left unequal. These neurochemical changes are the central physiological cause of addiction.</p>		\n										<img width=\"124\" height=\"153\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Vector.png\" alt=\"\" loading=\"lazy\" />											\n			<h2>Schedule a <orange>FREE</orange> consultation \nwith one of our physicians today\n</h2>		\n			<a href=\"https://anrclinic.nirazo.me/contact/\" role=\"button\">\n						CLICK HERE\n					</a>\n			<h3>Dangers of OxyContin prescription</h3>		\n		<p>Many individuals are prescribed strong medications like OxyContin for simple procedures such as wisdom teeth removal or minor surgeries. Often OxyContin prescriptions are refilled without a full medical exam, or overprescribed to save patients the trip back to the doctor’s office. This can lead to extra OxyContin pills being sold on the streets and an increase in the number of individuals suffering from opioid dependency.</p><p>This poorly regulated system is the main contributor to individuals becoming addicted to OxyContin. Those abusing OxyContin need to be aware that many fraudulent street pills have been cut and laced with fentanyl to ensure you stay addicted and keep spending money.</p>		\n										<img width=\"620\" height=\"1024\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-620x1024.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-620x1024.jpg 620w, https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-182x300.jpg 182w, https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-768x1268.jpg 768w, https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-930x1536.jpg 930w, https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-1240x2048.jpg 1240w, https://anrclinic.nirazo.me/wp-content/uploads/2020/08/Oxycontin-Withdrawal-ANR-Clinic-scaled.jpg 1550w\" sizes=\"(max-width: 620px) 100vw, 620px\" />											\n			<h2>OxyContin dependence and addiction</h2>		\n		<p>Narcotic</p>\n<p>It can treat moderate to severe pain.</p>\n<p>Controlled substance</p>\n<p>High risk for addiction and dependence. Can cause respiratory distress and death when taken in high doses or when combined with other substances, especially alcohol.<br>(<a href=\"https://drugfree.org/drugs/prescription-pain-relievers-opioids\" target=\"_blank\" rel=\"noopener noreferrer\">source</a>)</p>\n<p>An individual who abuses OxyContin creates a measurable chemical imbalance. Although the brain will try to respond to this increase in endorphin receptors naturally, it cannot. Therefore, the tolerance to OxyContin increases to satisfy the brain’s endorphin receptors. This tolerance inevitably leads to Oxycontin dependence and addiction. Dependence is the need to continue taking a drug to avoid withdrawal symptoms, regardless of negative consequences. Addiction describes the intense cravings for OxyContin and compulsive drug use over a period of time.</p>\n<p>Since our brains are in a constant state of seeking balance, OxyContin dependence can be thought of as a form of supply and demand. By supplying the brain with an external opioid (like OxyContin) endorphin receptors are increased, which leads to an increase in demand. When this happens, our brain is in a dangerous state, requiring more and more OxyContin to satisfy the increase in cravings.</p>\n<p>Long-term OxyContin usage can lead to physical tolerance. This occurs when the brain creates more receptors than there are endorphins to bind with. Put simply, the longer you take OxyContin, the higher dose you will need to experience the same effects. This can create various issues like prescriptions running out suspiciously quickly or the price of drugs becoming a financial burden. If an addict can no longer access the drug, they may experience OxyContin withdrawal.</p>		\n			<h2>Quick Navigation</h2>		\n			<p><a href=\"#OxyContin-Withdrawal-Treatment\">OxyContin Withdrawal Treatment\n</a></p>		\n			<p><a href=\"#OxyContin-effects\">OxyContin effects</a></p>		\n			<p><a href=\"#Dangers-of-OxyContin-prescription\">Dangers of OxyContin prescription</a></p>		\n			<p><a href=\"#OxyContin-dependence-and-addiction\">OxyContin dependence and addiction</a></p>		\n			<p><a href=\"#Oxycontin-withdrawal-symptoms\">Oxycontin withdrawal symptoms</a></p>		\n			<p><a href=\"#Oxycontin-withdrawal-timeline\">Oxycontin withdrawal timeline</a></p>		\n			<p><a href=\"#Detox-and-withdrawal-treatment-for-OxyContin\">Detox and withdrawal treatment  for OxyContin</a></p>		\n			<p><a href=\"#Benefits-of-ANR-treatment-for-OxyContin-withdrawal\">Benefits of ANR treatment for OxyContin withdrawal</a></p>		\n			<p><a href=\"#ANR-withdrawal-treatment-facility\">ANR treatment facility</a></p>		\n			<p><a href=\"#OxyContin-rehabilitation\">OxyContin rehabilitation</a></p>		\n			<h2>Become Oxycontin Free With ANR</h2>		\n			<h2>Other Opioid Treatments</h2>		\n				<nav data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-justify&quot;&gt;&lt;/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;/i&gt;\" data-full-width=\"yes\"><ul id=\"menu-1-3fdc4602\"><li id=\"menu-item-3273\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/codeine-withdrawal/\" class = \"hfe-menu-item\">Codeine Treatment</a></li>\n<li id=\"menu-item-3274\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/vicodin-withdrawal/\" class = \"hfe-menu-item\">Vicodin Treatment</a></li>\n<li id=\"menu-item-3276\"></li>\n<li id=\"menu-item-3277\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/methadone-withdrawal/\" class = \"hfe-menu-item\">Methadone Treatment</a></li>\n<li id=\"menu-item-3278\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/oxycodone-withdrawal/\" class = \"hfe-menu-item\">Oxycodone Treatment</a></li>\n<li id=\"menu-item-3279\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/percocet-withdrawal/\" class = \"hfe-menu-item\">Percocet Treatment</a></li>\n<li id=\"menu-item-3318\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/hydrocodone-withdrawal/\" class = \"hfe-menu-item\">Hydrocodone Treatment</a></li>\n<li id=\"menu-item-3474\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/subutex-withdrawal/\" class = \"hfe-menu-item\">Subutex Treatment</a></li>\n<li id=\"menu-item-3475\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/morphine-withdrawal/\" class = \"hfe-menu-item\">Morphine Treatment</a></li>\n<li id=\"menu-item-3606\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/heroin-withdrawal/\" class = \"hfe-menu-item\">Heroin Treatment</a></li>\n<li id=\"menu-item-3623\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/fentanyl-withdrawal/\" class = \"hfe-menu-item\">Fentanyl Treatment</a></li>\n<li id=\"menu-item-4075\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/suboxone-withdrawal/\" class = \"hfe-menu-item\">Suboxone Treatment</a></li>\n<li id=\"menu-item-4660\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/kratom-withdrawal/\" class = \"hfe-menu-item\">Kratom Treatment</a></li>\n<li id=\"menu-item-5868\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/oxycontin-withdrawal/\" class = \"hfe-menu-item\">Oxycontin Center</a></li>\n</ul></nav>              \n										<img width=\"124\" height=\"153\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Vector.png\" alt=\"\" loading=\"lazy\" />											\n			<h2>Schedule a <orange>FREE</orange> consultation \nwith one of our physicians today\n</h2>		\n			<a href=\"https://anrclinic.nirazo.me/contact/\" role=\"button\">\n						CLICK HERE\n					</a>\n			Oxycontin withdrawal symptoms		\n		<p>OxyContin affects the neurons in the brain. The opioid receptors in the brain are what OxyContin and other types of opioids bind to, which gives the substance its sought after, euphoric effect.</p><p>When OxyContin is abused, the body becomes accustomed to the surplus of endorphins in the system. The body is forced to adjust how nerve and brain signaling occur. It is important to note that when there is a drop in dopamine, especially a drop as extreme as stopping OxyContin, the consequences can be devastating.</p><h3>Physical symptoms of OxyContin withdrawal</h3> <p>The symptoms of OxyContin withdrawal are vast and harmful when not done within the proper medical parameters. Enhanced pain is a common symptom of OxyContin withdrawal as many addicts started taking the medication due to an injury or chronic pain.</p><p>Physical OxyContin withdrawal symptoms can also include:</p><ul><li> Nausea or vomiting</li><li>Rapid heart rate</li><li> Blood pressure changes</li><li> Seizures</li><li> Abdominal cramping and diarrhea</li><li> Reduced energy, difficulty breathing and unconsciousness</li><li> Flu-like symptoms such as a runny nose, fever, sweating, muscle limpness, and</li><li>drowsiness</li></ul><p>An individual must be under medical care during this withdrawal period to ensure safety.</p><h3>Psychological symptoms of OxyContin withdrawal</h3> <p>Psychological effects such as insomnia is also common. As a result of abusing OxyContin, individuals may have experienced the loss of relationships or employment. Only when the individual is in withdrawal do they begin to realize these losses for what they are, making it harder to focus, stay calm, and sleep.</p><p>OxyContin’s long-term use has complex and long-lasting impacts on the brain. When the individual stops taking OxyContin, the central nervous system is suddenly forced to change how it sends neurotransmitter signals. This can result in the following psychological withdrawal symptoms:</p><ul><li>Restlessness </li><li>Anxiety</li><li>IIrritability</li><li> Depression</li><li> Hallucinations</li></ul><p>Going through the withdrawal process alone is extremely daunting and potentially dangerous, highlighting the importance of doing so in a fully-equipped facility. Better yet, seeking treatment for OxyContin addiction at the <a href=\"https://anrclinic.nirazo.me/\">ANR Clinic</a> allows individuals to avoid these painful withdrawal symptoms altogether.</p>		\n			<h2>From the Blog</h2>		\n                <article data-id=\"1361\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/just-who-is-affected-by-the-opioid-epidemic/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/12/who-is-affected-by-opioid-1-e1576785093854-300x200.jpg\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/just-who-is-affected-by-the-opioid-epidemic/\"\n                title=\"Just Who Is Affected by The Opioid Epidemic?\"\n                >Just Who Is Affected by The Opioid Epidemic?</a></h2></header>\n                    </article><article data-id=\"648\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/facts-about-opiate-addiction-and-treatment/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/09/factsaboutopiateaddiction-300x225.jpg\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/facts-about-opiate-addiction-and-treatment/\"\n                title=\"Facts About Opiate Addiction and Treatment\"\n                >Facts About Opiate Addiction and Treatment</a></h2></header>\n                    </article><article data-id=\"447\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team-2/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/09/Picture1-300x199.png\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team-2/\"\n                title=\"Vitamin D Receptors\"\n                >Vitamin D Receptors</a></h2></header>\n                    </article><article data-id=\"442\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/09/Picture12-300x211.png\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team/\"\n                title=\"Breaking Windows\"\n                >Breaking Windows</a></h2></header>\n                    </article>\n			Oxycontin withdrawal timeline		\n		<p>One of the factors causing OxyContin to be highly sought after is the long-acting release that allows it to affect the body over several hours. As a result, the withdrawal lasts longer than withdrawal from an opioid such as heroin, which is short-acting.</p><p>Although the OxyContin detox timeline varies, it is most common to see initial symptoms of OxyContin withdrawal anywhere from 12 to 48 hours after its last use. Lingering withdrawal effects have been reported for as long as six months after stopping. Within this period of time, people experience powerful desires for OxyContin and the likelihood of relapse is high.</p><p>Known factors that contribute to the duration and intensity of OxyContin withdrawal symptoms include:</p><ul><li> Dosage</li><li> How slowly the drug has been tapered off of</li><li> The overall health of an individual</li><li> Other medications a person is, or was, taking</li><li> Physical exercise and exertion</li></ul><p>The following is an example of what someone may experience during active Oxycontin withdrawal.</p><h3>24 to 48 hours after the last dose</h3> <p>The first symptoms that tend to arise include vomiting, nausea, headaches, runny nose, extreme sweating, anxiety, and appetite loss. The first two days of the detox are the most vital to a person’s recovery since they are most at risk of giving in to cravings.</p><h3>3 to 5 days after the last dose</h3> <p>The worst and most painful physical symptoms tend to occur during this stage. Intense muscle aches, cramps, shaking, vomiting, and nausea are common amongst nearly all individuals undergoing OxyContin withdrawal.</p><h3>5 to 10 days after the last dose</h3> <p>At this point, OxyContin’s physical withdrawal symptoms begin to subside, which may be replaced by psychological withdrawal symptoms like anxiety and depression.</p><h3>10 days +</h3> <p>Psychological effects continue to manifest. Guilt, anxiety, and cravings can occur long after the last use of the drug.</p>		\n											<a href=\"tel:8137507470\">\n							<img width=\"917\" height=\"352\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Group-117589.png\" alt=\"Kratom Withdrawal - ANR Clinic\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Group-117589.png 917w, https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Group-117589-300x115.png 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/06/Group-117589-768x295.png 768w\" sizes=\"(max-width: 917px) 100vw, 917px\" />								</a>\n			<h3>Detox and withdrawal treatment for OxyContin</h3>		\n		<p>Refusing to provide the body with OxyContin by quitting cold turkey often leads to unpleasant and dangerous physical symptoms known as OxyContin withdrawal.</p><p>Opioid dependence is not a matter of personality or willpower, as many treatment facilities would like you to believe. Rather, dependence is caused by your brain’s neuro-biophysical state being changed.</p><p>Oxycontin dependency is most commonly treated with medication therapy which consists of a doctor prescribing methadone, naltrexone, or buprenorphine in a drug detoxification rehab facility. However, when detoxing in such a way, it causes the brain and its endorphins to continue in a deregulated state. It is also extremely common for individuals to begin abusing these new drugs and further their addiction.</p><h3>Fast, or rapid OxyContin detox</h3> <p><a style=\"font-size: 15px; background-color: #ffffff;\" href=\"https://anrclinic.nirazo.me/dr-andre-waismann/\" target=\"_blank\" rel=\"noopener noreferrer\">Dr. Andre Waismann</a>, the founder of the ANR Clinic and treatment, established the foundation for opioid medical detox treatment with the development of ‘Rapid Detox’ in the 1990s.</p><p><a style=\"font-size: 15px; background-color: #ffffff;\" href=\"https://anrclinic.nirazo.me/anr-is-not-rapid-detox/\" target=\"_blank\" rel=\"noopener noreferrer\">Rapid detox</a> has since become a leading method for treating opioid withdrawal symptoms in inpatient treatment programs and drug rehab facilities. Over time, however, Dr. Waismann noticed that many of these programs that had implemented rapid detox did so without the knowledge required to achieve desirable results safely. Consequently, patients suffered and were left with a high chance of relapse.</p><h3>Accelerated Neuro-Regulation (ANR) treatment</h3> <p>Dr. Waismann sought a more advanced solution for his patients, eventually developing what is now known as Accelerated Neuro-Regulation treatment (ANR). Removing opioids from the body does not do anything to treat the brain’s fundamental imbalance - the root of opioid addiction. ANR is the only treatment option of its kind, medically proven to solve opioid addiction by reversing the imbalance that caused the OxyContin dependency.</p><p>Changes to the brain’s structure and function, due to substance abuse, may persist for months and, if left untreated, often result in relapse. The endorphin-receptor balance needs to be completely resolved to achieve substantial, long-lasting results in the treatment of opioid addiction.</p>		\n			Benefits of ANR treatment for OxyContin withdrawal		\n		<p>ANR eliminates cravings and the fear of relapse - something that has never been done before. By evaluating each patient’s specific endorphin-receptor balance, the ANR method of treatment for opioid withdrawal is tailored to each person’s neuro-biological needs, making it an incredibly effective treatment method over and traditional rehab or detox center, including “Rapid Detox.”</p><p>Accelerated Neuro-Regulation is the most desired and accepted answer to address opioid dependency and is backed by science. As of this year, over 24,000 patients internationally have been successfully treated using ANR.</p><p>Accelerated Neuro-Regulation can treat the underlying cause of OxyContin dependence in a clinically proven, effective, and humane way. ANR is an innovative medical alternative to outdated, poor outcome practices. These older methods of withdrawal treatment have a habit of keeping someone addicted to opioids, stuck in a perpetual cycle of using, abusing, attempting rehabilitation, and subsequent relapsing.</p><p>Our process of targeting the physiological mechanism behind dependency allows patients to finally return to the life they once knew and loved prior to their OxyContin addiction, without the constant threat and fear of a relapse.</p><p><strong>ANR is the only treatment available in the world that treats the ROOT of the dependency that takes place in the brain. </strong>Others only address the secondary effects - the withdrawals.</p><p>Over the past several decades receiving addiction treatment has been a long, complicated, expensive process that yields minimal results. With ANR, opioid addiction treatment can be as easy as calling us to see if you are a candidate and making an appointment for a procedure.</p><p>From the time you enter our facility, until our highly trained and licensed medical professionals deem you fit to be released, you would have received your lifelong addiction treatment in less than 30 hours.</p>		\n			<h3>ANR treatment facility</h3>		\n		<p>The actual ANR treatment method for Oxycontin addiction is complete in approximately 4-5 hours. A 30-hour stay at Landmark Hospital in Naples, Florida, is the total amount of time needed for a patient to be adequately monitored pre and post-procedure.</p><p>Upon arrival, patients will be admitted into the hospital’s ANR unit where they will undergo a comprehensive medical evaluation. Following an extensive review of the individual patient’s endorphin-receptor status, the procedure is tailored accordingly to achieve endorphin-receptor re-regulation.</p><p>At the time of discharge, patients, and their loved ones, can expect to leave with peace of mind knowing that they are no longer dependent on OxyContin.</p>		\n			<h3>OxyContin rehabilitation through ANR treatment\n</h3>		\n		<p>The fear of withdrawal from OxyContin is as understandable as it is painful and intimidating. On a daily basis, it prevents thousands of individuals from entering a rehab facility or detox program. Hence why entering a long-term residential facility, with other individuals around to witness your experience, to overcome OxyContin addiction can be a huge, daunting commitment, both financially and otherwise.</p><p>ANR Clinic in Naples, Florida, is here to help you overcome your opioid addiction without an unnecessarily long stay. Being able to overcome addiction and the promise of being able to tend to life’s regular routines and obligations only aids your recovery. Over one weekend, and without missing out on life’s special events, work, and time with friends and family, ANR treatment provides you the chance to get back to your normal life, free from addiction to OxyContin.</p><p>The Accelerated Neuro-Regulation treatment is performed by a team of highly qualified medical professionals, in a modern hospital ICU. It is considered the most effective and efficient treatment for OxyContin dependence at this time.</p><p>Never blame yourself for failed attempts at weaning or tapering off OxyContin. It is an extremely difficult and nearly impossible task for hundreds of thousands of people. Until now, OxyContin addiction treatment at rehab facilities has been focused on symptom management, rather than the physiological imbalance in the brain.</p><p>Simply put, detoxing the drug from your system does not leave an individual in the clear from their opioid addiction. Your brain is still left with more receptors than endorphins, which drives the intense, never-ending cravings.</p><p>OxyContin dependence is a manifestation of brain changes resulting from prolonged OxyContin use. As long as there is an imbalance in the brain, the OxyContin dependence will always remain. Treatment at Florida’s ANR Clinic can restore the brain’s altered endorphin-receptor balance, eliminating the underlying cause of OxyContin dependence, and leaving individuals free from their life of opioid addiction.</p>		\n			<h2>Another Opioid Treatments</h2>		\n				<nav data-toggle-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;fas fa-align-justify&quot;&gt;&lt;/i&gt;\" data-close-icon=\"&lt;i aria-hidden=&quot;true&quot; tabindex=&quot;0&quot; class=&quot;far fa-window-close&quot;&gt;&lt;/i&gt;\" data-full-width=\"yes\"><ul id=\"menu-1-3985a8a2\"><li id=\"menu-item-3273\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/codeine-withdrawal/\" class = \"hfe-menu-item\">Codeine Treatment</a></li>\n<li id=\"menu-item-3274\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/vicodin-withdrawal/\" class = \"hfe-menu-item\">Vicodin Treatment</a></li>\n<li id=\"menu-item-3276\"></li>\n<li id=\"menu-item-3277\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/methadone-withdrawal/\" class = \"hfe-menu-item\">Methadone Treatment</a></li>\n<li id=\"menu-item-3278\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/oxycodone-withdrawal/\" class = \"hfe-menu-item\">Oxycodone Treatment</a></li>\n<li id=\"menu-item-3279\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/percocet-withdrawal/\" class = \"hfe-menu-item\">Percocet Treatment</a></li>\n<li id=\"menu-item-3318\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/hydrocodone-withdrawal/\" class = \"hfe-menu-item\">Hydrocodone Treatment</a></li>\n<li id=\"menu-item-3474\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/subutex-withdrawal/\" class = \"hfe-menu-item\">Subutex Treatment</a></li>\n<li id=\"menu-item-3475\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/morphine-withdrawal/\" class = \"hfe-menu-item\">Morphine Treatment</a></li>\n<li id=\"menu-item-3606\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/heroin-withdrawal/\" class = \"hfe-menu-item\">Heroin Treatment</a></li>\n<li id=\"menu-item-3623\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/fentanyl-withdrawal/\" class = \"hfe-menu-item\">Fentanyl Treatment</a></li>\n<li id=\"menu-item-4075\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/suboxone-withdrawal/\" class = \"hfe-menu-item\">Suboxone Treatment</a></li>\n<li id=\"menu-item-4660\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/kratom-withdrawal/\" class = \"hfe-menu-item\">Kratom Treatment</a></li>\n<li id=\"menu-item-5868\"><a href=\"https://anrclinic.nirazo.me/opioid-withdrawal-treatment/oxycontin-withdrawal/\" class = \"hfe-menu-item\">Oxycontin Center</a></li>\n</ul></nav>              \n			<h2>From the Blog</h2>		\n                <article data-id=\"1361\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/just-who-is-affected-by-the-opioid-epidemic/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/12/who-is-affected-by-opioid-1-e1576785093854-300x200.jpg\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/just-who-is-affected-by-the-opioid-epidemic/\"\n                title=\"Just Who Is Affected by The Opioid Epidemic?\"\n                >Just Who Is Affected by The Opioid Epidemic?</a></h2></header>\n                    </article><article data-id=\"648\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/facts-about-opiate-addiction-and-treatment/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/09/factsaboutopiateaddiction-300x225.jpg\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/facts-about-opiate-addiction-and-treatment/\"\n                title=\"Facts About Opiate Addiction and Treatment\"\n                >Facts About Opiate Addiction and Treatment</a></h2></header>\n                    </article><article data-id=\"447\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team-2/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/09/Picture1-300x199.png\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team-2/\"\n                title=\"Vitamin D Receptors\"\n                >Vitamin D Receptors</a></h2></header>\n                    </article><article data-id=\"442\">\n                            <a\n                                        href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team/\"\n                                    ></a>\n                                <img src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/09/Picture12-300x211.png\" alt=\"\">\n                            <header><h2><a\n                href=\"https://anrclinic.nirazo.me/blog/anr-clinic-team/\"\n                title=\"Breaking Windows\"\n                >Breaking Windows</a></h2></header>\n                    </article>\n			<h2>Fill out this form so that \n<br>we can immediately reverse your opiate addiction</h2>		\n			<a href=\"#form\" role=\"button\">\n						CLICK HERE\n					</a>','withdrawal page save copy','','publish','closed','closed','','withdrawal-page-save-copy','','','2020-10-08 17:28:38','2020-10-08 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04:30:42','','','','publish','closed','closed','','7810','','','2020-11-11 23:30:42','2020-11-12 04:30:42','',0,'https://anrclinic.nirazo.me/nf_sub/7810/',0,'nf_sub','',0),(7811,0,'2020-11-12 00:05:34','2020-11-12 05:05:34','','','','publish','closed','closed','','7811','','','2020-11-12 00:05:34','2020-11-12 05:05:34','',0,'https://anrclinic.nirazo.me/nf_sub/7811/',0,'nf_sub','',0),(7812,0,'2020-11-12 05:36:45','2020-11-12 10:36:45','','','','publish','closed','closed','','7812','','','2020-11-12 05:36:45','2020-11-12 10:36:45','',0,'https://anrclinic.nirazo.me/nf_sub/7812/',0,'nf_sub','',0),(7813,0,'2020-11-12 09:25:05','2020-11-12 14:25:05','','','','publish','closed','closed','','7813','','','2020-11-12 09:25:05','2020-11-12 14:25:05','',0,'https://anrclinic.nirazo.me/nf_sub/7813/',0,'nf_sub','',0),(7814,0,'2020-11-12 09:27:41','2020-11-12 14:27:41','','','','publish','closed','closed','','7814','','','2020-11-12 09:27:41','2020-11-12 14:27:41','',0,'https://anrclinic.nirazo.me/nf_sub/7814/',0,'nf_sub','',0),(7815,0,'2020-11-12 09:30:09','2020-11-12 14:30:09','','','','publish','closed','closed','','7815','','','2020-11-12 09:30:09','2020-11-12 14:30:09','',0,'https://anrclinic.nirazo.me/nf_sub/7815/',0,'nf_sub','',0),(7817,0,'2020-11-12 12:13:10','2020-11-12 17:13:10','','','','publish','closed','closed','','7817','','','2020-11-12 12:13:10','2020-11-12 17:13:10','',0,'https://anrclinic.nirazo.me/nf_sub/7817/',0,'nf_sub','',0),(7818,0,'2020-11-12 12:15:23','2020-11-12 17:15:23','','','','publish','closed','closed','','7818','','','2020-11-12 12:15:23','2020-11-12 17:15:23','',0,'https://anrclinic.nirazo.me/nf_sub/7818/',0,'nf_sub','',0),(7821,0,'2020-11-12 14:09:16','2020-11-12 19:09:16','','','','publish','closed','closed','','7821','','','2020-11-12 14:09:16','2020-11-12 19:09:16','',0,'https://anrclinic.nirazo.me/nf_sub/7821/',0,'nf_sub','',0),(7822,0,'2020-11-12 14:17:12','2020-11-12 19:17:12','','','','publish','closed','closed','','7822','','','2020-11-12 14:17:12','2020-11-12 19:17:12','',0,'https://anrclinic.nirazo.me/nf_sub/7822/',0,'nf_sub','',0),(7823,0,'2020-11-12 14:27:17','2020-11-12 19:27:17','','','','publish','closed','closed','','7823','','','2020-11-12 14:27:17','2020-11-12 19:27:17','',0,'https://anrclinic.nirazo.me/nf_sub/7823/',0,'nf_sub','',0),(7824,0,'2020-11-12 14:39:37','2020-11-12 19:39:37','','','','publish','closed','closed','','7824','','','2020-11-12 14:39:37','2020-11-12 19:39:37','',0,'https://anrclinic.nirazo.me/nf_sub/7824/',0,'nf_sub','',0),(7825,0,'2020-11-12 15:04:24','2020-11-12 20:04:24','','','','publish','closed','closed','','7825','','','2020-11-12 15:04:24','2020-11-12 20:04:24','',0,'https://anrclinic.nirazo.me/nf_sub/7825/',0,'nf_sub','',0),(7826,2,'2020-11-12 15:04:54','2020-11-12 20:04:54','<h2>You\'ve Tried <orangetext>Rehab,</orangetext></h2>		\n			<h2>Now it\'s Time for <orangetext>Medicine.</orangetext>\n</h2>		\n		<p>ANR is the <strong>only available</strong> opiate addiction treatment that allows patients to avoid withdrawals and bring the patient\'s biology into a pre-addiction state.</p><p>ANR Treatment is now in America.</p>		\n			<a href=\"#formlink\" role=\"button\">\n						Schedule Free Consultation\n					</a>\n			<a href=\"tel:+18137507470\" role=\"button\">\n						Call Us (813) 750-7470\n					</a>\n					<ul>\n							<li>\n										100% Confidential\n									</li>\n								<li>\n										No Obligation\n									</li>\n						</ul>\n										<img width=\"192\" height=\"33\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/12/usa-today.png\" alt=\"\" loading=\"lazy\" />											\n										<img width=\"80\" height=\"80\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/12/fox-news-logo.jpg\" alt=\"\" loading=\"lazy\" />											\n										<img width=\"200\" height=\"37\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/12/iHeartRadio_blogpost-01.jpg\" alt=\"\" loading=\"lazy\" />											\n										<img width=\"181\" height=\"36\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2019/12/independent.png\" alt=\"\" loading=\"lazy\" />											\n			<h2>ANR allows individuals to return to the life they led before opioid addiction in as little as <orangetext>48 hours.</orangetext></h2>		\n			<a href=\"https://anrclinic.nirazo.me/treatment/\" role=\"button\">\n						Find Out More\n					</a>\n			<a href=\"tel:+18137507470\" role=\"button\">\n						Call Us (813) 750-7470\n					</a>\n										<img width=\"500\" height=\"500\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/07/hospital-img.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/07/hospital-img.jpg 500w, https://anrclinic.nirazo.me/wp-content/uploads/2020/07/hospital-img-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/07/hospital-img-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/07/hospital-img-45x45.jpg 45w\" sizes=\"(max-width: 500px) 100vw, 500px\" />											\n			<h2>How it Works</h2>		\n				1\n			<h3>Hospital Admission</h3>		\n		<p>Admission to the ANR unit, laboratory testing and a comprehensive clinical evaluation. Pre-medication during this period allows for a comfortable transition into the treatment.</p>		\n				2\n			<h3>The Treatment</h3>		\n		<p>The patient is sedated for approximately 4-5 hours. While under sedation, their endorphins and opioid receptors are regulated/modulated until the pre-dependency balance has been achieved.</p>		\n				3\n			<h3>Recovery</h3>		\n		<p>The first stage of recovery begins. The patient continues to be evaluated and his or her endorphin-receptor balance can be fine-tuned during this time if required.</p>		\n				4\n			<h3>Discharge</h3>		\n		<p>In the morning, patients are encouraged to shower, eat, and gradually begin physical activities. Most patients will be discharged from the hospital later that day.</p>		\n			<h3>Experts on ANR</h3>		\n		https://www.youtube.com/watch?v=VNPUxSvNOYI&#038;t=44sDr. John Currie (Autralia) https://www.youtube.com/watch?v=6I6HXVLXG3w&#038;t=14sTrish Freeman, RN\nhttps://www.youtube.com/watch?v=i0A9MYUlGUM&#038;t=44sDr. Daniel Beutler (Switzerland)  https://www.youtube.com/watch?v=QXYfA4gBZxg&#038;t=24sDr. Albert Kabemba		\n									<figure><img width=\"309\" height=\"309\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd.jpg 309w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd-45x45.jpg 45w\" sizes=\"(max-width: 309px) 100vw, 309px\" /></figure>\n				<p>\"Dr. Waismann focuses the team meticulously on every detail of the treatment. He assures a desired outcome for the patients of neuro-regulation to achieve the therapeutic goal of neuro-equilibrium. We are privileged to be working with Dr. Waismann in his mission to free people from opiate addiction. Dr. Waismann’s dedication to his patient’s well-being is infectious. He is crystal clear in communicating his belief that each person is uniquely individual and must be treated as such, with dignity and respect.\"</p>\n					<p>Susan Bailey,</p><p>CEO Landmark Hospital (USA)</p>				\n									<figure><img width=\"200\" height=\"200\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large.jpg 200w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large-45x45.jpg 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" /></figure>\n				<p>\"Based on profound analysis of the scientific literature and data, we have reached the following conclusion: it is a medical procedure that has a firm pharmacological basis. This procedure provides a number of advantages: the patient undergoes the procedure with minimal risk and stress. The fact that patients have successfully completed the procedure without any medical complications or mortality cases proves that this method is safe and efficient.\"</p>\n				<p>Professor Yehuda Sheinfeld (Israel)</p>\n									<figure><img width=\"300\" height=\"300\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-300x300.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-1024x1024.jpg 1024w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-768x768.jpg 768w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-45x45.jpg 45w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o.jpg 1418w\" sizes=\"(max-width: 300px) 100vw, 300px\" /></figure>\n				<p>\"ANR Treatment had tremendous success when it performed here in Romania. Patients were successfully treated and freed from their dependency. Even with a selection of the worst cases, the results were excellent.\"</p>\n					<p>Prof Cristian Ene, President of the Antidrug Forum Association (Romania)</p>				\n									<figure><img width=\"500\" height=\"500\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image.jpg 500w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image-45x45.jpg 45w\" sizes=\"(max-width: 500px) 100vw, 500px\" /></figure>\n				<p>\"It is important to emphasize that the treatment has a solid scientific background. The proof for its success relies on the fact that 100% of the patients overcome the physical opiate dependency. Dr. Waismann’s clinic uses a technology that grants every patient the opportunity to start a new life free of opiate addiction.\"</p>\n				<p>Dr. Rezo Davituliani  (Georgia)</p>\n									<figure><img width=\"225\" height=\"225\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download.jpg 225w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download-45x45.jpg 45w\" sizes=\"(max-width: 225px) 100vw, 225px\" /></figure>\n				<p>\"Based on the scientific literature and accumulated experience in Israel and Europe, one may conclude that ANR is a highly efficient method.  If carried out in optimal professional conditions, ANR can have a 100% success rate. This method has a significant advantage over other conventional methods: a minimal percentage of dropout cases versus reported 30%-60% (of dropouts with other methods).\"</p>\n					<p>Prof M Kotler,  Chair of the National Mental Health Council (Israel)</p>				\n									<figure><img width=\"512\" height=\"512\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd.jpg 512w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd-45x45.jpg 45w\" sizes=\"(max-width: 512px) 100vw, 512px\" /></figure>\n				<p>\"It is one of the most efficient methods that we know, and we welcome it in Israel. The research conducted in the USA shows that the shorter and less painful the physical withdrawal is, the faster the recovery of the patient.\"</p>\n				<p>Dr. A. Lerner (Israel)</p>\n									<figure><img width=\"500\" height=\"500\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image.jpg 500w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image-45x45.jpg 45w\" sizes=\"(max-width: 500px) 100vw, 500px\" /></figure>\n				<p>\"ANR treatment protocol is an effective and exceptionally safe treatment. It reverses opioid dependency with the use of advanced modern medicine.\"</p>\n					<p>Dr. B Pablo, Chief of the Anesthesia Department, Barzilai Medical Center (Israel)</p>				\n									<figure><img width=\"281\" height=\"300\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/07/picturemessage_utyh3zw0.o5m.png\" alt=\"\" loading=\"lazy\" /></figure>\n				<p>\"The only one to answer was Dr. Andre Waismann. He not only offered advice but asked me to send him the boy’s case history. He then rang back and offered to come here, to assemble a medical team who could assist and learn from him, and to operate on Endriss free of charge.\"</p>\n				<p>Dr. Matamoros, Costa RicaImage (Costa Rica)</p>\n									<figure><img width=\"323\" height=\"366\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/03/picturemessage_0faa5umw.nbo_.png\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/03/picturemessage_0faa5umw.nbo_.png 323w, https://anrclinic.nirazo.me/wp-content/uploads/2020/03/picturemessage_0faa5umw.nbo_-265x300.png 265w\" sizes=\"(max-width: 323px) 100vw, 323px\" /></figure>\n				<p>\"ANR has shown to be an essential step towards offering opiate addicts a full treatment for a potentially lethal condition. Among the existing therapies, ANR is the only one that proposes an effective way of winning over withdrawal syndrome.\"</p>\n					<p>Tal Rauchwerger, Medical Researcher & Consultant (Israel)</p>				\n									<figure><img width=\"250\" height=\"250\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a.png\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a.png 250w, https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a-150x150.png 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a-45x45.png 45w\" sizes=\"(max-width: 250px) 100vw, 250px\" /></figure>\n				<p>\"What I saw after the treatment is something I never saw before. There are no cravings at all. This is amazing. ANR is not only the best treatment for opioid dependency; ANR is the only treatment for opioid dependency.\"</p>\n				<p>Dr. Daniel Beutler (Switzerland)</p>\n			<h3>Experts on ANR</h3>		\n		https://www.youtube.com/watch?v=VNPUxSvNOYI&#038;t=44sDr. John Currie (Autralia) https://www.youtube.com/watch?v=6I6HXVLXG3w&#038;t=14sTrish Freeman, RN\nhttps://www.youtube.com/watch?v=i0A9MYUlGUM&#038;t=44sDr. Daniel Beutler (Switzerland)  https://www.youtube.com/watch?v=QXYfA4gBZxg&#038;t=24sDr. Albert Kabemba		\n				<p>\"Dr. Waismann focuses the team meticulously on every detail of the treatment. He assures a desired outcome for the patients of neuro-regulation to achieve the therapeutic goal of neuro-equilibrium. We are privileged to be working with Dr. Waismann in his mission to free people from opioid addiction. Dr. Waismann’s dedication to his patient’s well-being is infectious. He is crystal clear in communicating his belief that each person is uniquely individual and must be treated as such, with dignity and respect.\"</p>\n									<figure><img width=\"309\" height=\"309\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd.jpg 309w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/20f2ae41-576f-41a0-b0a7-26abc327b9dd-45x45.jpg 45w\" sizes=\"(max-width: 309px) 100vw, 309px\" /></figure>\n							<p>Susan Bailey,</p><p>CEO Landmark Hospital (USA)</p>\n				<p>Based on profound analysis of the scientific literature and data, we have reached the following conclusion: it is a medical procedure that has a firm pharmacological basis. This procedure provides a number of advantages: the patient undergoes the procedure with minimal risk and stress. The fact that patients have successfully completed the procedure without any medical complications or mortality cases proves that this method is safe and efficient</p>\n									<figure><img width=\"200\" height=\"200\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large.jpg 200w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/sheinfeld_300x3001-large-45x45.jpg 45w\" sizes=\"(max-width: 200px) 100vw, 200px\" /></figure>\n							<p>Professor Yehuda Sheinfeld (Israel)</p>\n				<p>\"ANR Treatment had tremendous success when it performed here in Romania. Patients were successfully treated and freed from their dependency. Even with a selection of the worst cases, the results were excellent.\"</p>\n									<figure><img width=\"300\" height=\"300\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-300x300.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-1024x1024.jpg 1024w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-768x768.jpg 768w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o-45x45.jpg 45w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/219086_394184207322173_870412766_o.jpg 1418w\" sizes=\"(max-width: 300px) 100vw, 300px\" /></figure>\n							<p>Professor Cristian Ene, President of the Antidrug Forum Association - FORAD (Romania)</p>\n				<p>\"It is important to emphasize that the treatment has a solid scientific background. The proof for its success relies on the fact that 100% of the patients overcome the physical opiate dependency. Dr. Waismann’s clinic uses a technology that grants every patient the opportunity to start a new life free of opioid addiction.\"</p>\n									<figure><img width=\"500\" height=\"500\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image.jpg 500w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/652_151551_team_image-45x45.jpg 45w\" sizes=\"(max-width: 500px) 100vw, 500px\" /></figure>\n							<p>Dr. Rezo Davituliani  (Georgia)</p>\n				<p>\"Based on the scientific literature and accumulated experience in Israel and Europe, one may conclude that ANR is a highly efficient method.  If carried out in optimal professional conditions, ANR can have a 100% success rate. This method has a significant advantage over other conventional methods: a minimal percentage of dropout cases versus reported 30%-60% (of dropouts with other methods).\"</p>\n									<figure><img width=\"225\" height=\"225\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download.jpg 225w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/download-45x45.jpg 45w\" sizes=\"(max-width: 225px) 100vw, 225px\" /></figure>\n							<p>Professor Moshe Kotler,  Chair of the National Mental Health Council (Israel)</p>\n				<p>\"It is one of the most efficient methods that we know, and we welcome it in Israel. The research conducted in the USA shows that the shorter and less painful the physical withdrawal is, the faster the recovery of the patient.\"</p>\n									<figure><img width=\"512\" height=\"512\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd.jpg 512w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/86a9bf70-4ae5-4d3e-baa8-eb87cd0544dd-45x45.jpg 45w\" sizes=\"(max-width: 512px) 100vw, 512px\" /></figure>\n							<p>Dr. A. Lerner (Israel)</p>\n				<p>\"ANR treatment protocol is an effective and exceptionally safe treatment. It reverses opioid dependency with the use of advanced modern medicine.\"</p>\n									<figure><img width=\"500\" height=\"500\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image.jpg\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image.jpg 500w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image-300x300.jpg 300w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image-150x150.jpg 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/02/439_390536_team_image-45x45.jpg 45w\" sizes=\"(max-width: 500px) 100vw, 500px\" /></figure>\n							<p>Dr. Boksenbojm Pablo, Chief of the Anesthesia Department, Barzilai Medical Center (Israel)</p>\n				<p>\"The only one to answer was Dr. Andre Waismann. He not only offered advice but asked me to send him the boy’s case history. He then rang back and offered to come here, to assemble a medical team who could assist and learn from him, and to operate on Endriss free of charge.\"</p>\n									<figure><img width=\"281\" height=\"300\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/07/picturemessage_utyh3zw0.o5m.png\" alt=\"\" loading=\"lazy\" /></figure>\n							<p>Dr. Matamoros, Costa RicaImage (Costa Rica)</p>\n				<p>\"ANR has shown to be an essential step towards offering opiate addicts a full treatment for a potentially lethal condition. Among the existing therapies, ANR is the only one that proposes an effective way of winning over withdrawal syndrome.\"</p>\n									<figure><img width=\"323\" height=\"366\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/03/picturemessage_0faa5umw.nbo_.png\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/03/picturemessage_0faa5umw.nbo_.png 323w, https://anrclinic.nirazo.me/wp-content/uploads/2020/03/picturemessage_0faa5umw.nbo_-265x300.png 265w\" sizes=\"(max-width: 323px) 100vw, 323px\" /></figure>\n							<p>Tal Rauchwerger, Medical Researcher & Consultant (Israel)</p>\n				<p>\"What I saw after the treatment is something I never saw before. There are no cravings at all. This is amazing. ANR is not only the best treatment for opioid dependency; ANR is the only treatment for opioid dependency.\"</p>\n									<figure><img width=\"250\" height=\"250\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a.png\" alt=\"\" loading=\"lazy\" srcset=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a.png 250w, https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a-150x150.png 150w, https://anrclinic.nirazo.me/wp-content/uploads/2020/06/picturemessage_fobmegkz.z0a-45x45.png 45w\" sizes=\"(max-width: 250px) 100vw, 250px\" /></figure>\n							<p>Dr. Daniel Beutler (Switzerland)</p>\n			<h2>We Have Treated More than <orangetext>24,000</orangetext> patients worldwide.</h2>		\n			<h2>Complete the form and schedule your free consultation today.</h2>		\n					<ul>\n							<li>\n										100% Confidential\n									</li>\n						</ul>\n					<ul>\n							<li>\n										No Obligation\n									</li>\n						</ul>\n		https://www.youtube.com/watch?v=sYHUcXcqDMA		\n			<h2>ANR\'s Success Around the World</h2>		\n		<p>Since 1992, Dr. Waismann and his team have led the fight in the global opioid epidemic. For more than 30 years, they have shared their expertise in ANR treatment for opioid dependency with government and health organizations from all around the world.</p>		\n<iframe id=\"leaflet\" onload=\"window.parent.scrollTo(0,0)\" allowtransparency=\"true\" allowfullscreen=\"true\" allow=\"geolocation; microphone; camera\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/Website%20Map/Website%20Map/main.html?desktop=1\" frameborder=\"0\" style=\"width: 1px; min-width: 100%; height:500px; border:none;\" scrolling=\"no\" > </iframe>		\n<iframe id=\"leaflet\" onload=\"window.parent.scrollTo(0,0)\" allowtransparency=\"true\" allowfullscreen=\"true\" allow=\"geolocation; microphone; camera\" src=\"https://anrclinic.nirazo.me/wp-content/uploads/2020/Website%20Map/Website%20Map/main.html?mobile=1\" frameborder=\"0\" style=\"width: 1px; min-width: 100%; height:250px; border:none;\" scrolling=\"no\" > </iframe>		\n			<h2>CALL 24/7 Admission Hotline: (813) 750-7470\n</h2>		\n			<a 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