Hi, I've been living with opioid addiction for about 4 years and just stumbled upon this ANR treatment for the first time. My understanding is that in order to maintain homeostasis, the brain acclimates by increasing opioid/endorphin receptors to accommodate for the increased amount of opioids continuously from frequent opioid use. Then when one abstains from using any opioid the brain goes into withdrawal because of the unnatural endorphin to endorphin receptor ratio. Over time the brain removes or possibly switches off receptors until it reaches the appropriate homeostasis for endorphins produced without opioids. So assuming that is more or less how opioid addiction works, I would guess that ANR treatment would involve somehow lowering the amount of endorphin receptors in the patient while sedated? My question is how is this done? Is the patient administered an opioid antagonist while sedated in order to go through precipitated withdrawal which perhaps could rapidly reduce the amount of receptors? Or is there a different process? If you could explain to me how and why ANR works that would be much appreciated, as I am interested in potentially seeing if this treatment could be a good option for me