Please note that the few cases in which I have been forced into withdrawals has been due to issue with a prescription. I have been on the medication or others similar for approximately 10 years. I take other medications for my RA including a monthly IV infusion of Actemra , along with Azathioprine and prednisone.  ( I’m also on anti depressants Bupropion 600mg) per day. It’s my understanding this can also be a contributor to endorphin imbalance.? 
My other conditions include minor hypertension which is treated with Losartan and hydrochlorothiazide. Hypogonadism treated with testosterone injections.